Cameron Winter springs the redneck hunters from "Cat And Mouse" from jail and uses them to pilot the 'Lizard Slayers': three extremely well-armed battle robots with one mission: to destroy Godzilla. When Cameron takes control of H.E.A.T.'s computer systems to stop them intervening, Nick and the others must get rid of Cameron, then find a way to save Godzilla from the attackers.

The team are called to San Francisco, where a group of giant mutated hummingbirds are attacking aircraft. The creatures move too fast for the naked eye to see them, making them impossible for Godzilla to fight. Now Mendel must rig up a special set of goggles that will allow Godzilla to see the birds, giving him a chance to fight back.

The team is split up due to a lawsuit by the state of Miami (over damages caused by a giant vampire bat). While Nick, Monique, and Elsie deal with the lawsuit, Randy and Mendel decide to deal with a mutant (without Nick's permission) in Michigan. The mutant in question is Armillaria, a giant fungus with the ability to suck the amino acids out of any living thing. It swiftly proves too much for the duo, who end up trapped in the wilderness with nothing but their wits and the clothes on their backs. Once the others hear of their antics, the race is on to rescue the duo and defeat Armillaria before it sucks Godzilla dry.