While fighting a giant mutant germ named Bacillus, Godzilla is infected by the bacteria and left fighting for his life. While Elsie, Randy and Mendel create an antibiotic to weaken the bacteria, Nick and Monique must enter Godzilla's body and destroy the infection at its source before Godzilla dies.

When Elsie's estranged parents come to New York for her spoiled sister's wedding, she is forced to attend as maid of honour instead of helping H.E.A.T capture a mutated manta ray. When the military's battle with the creature ends up interrupting the wedding, Elsie is determined not only to catch the creature, but to prove to her parents she is not the screw-up they think she is.

Shortly after receiving an anonymous check for $5 million, H.E.A.T. are called toIllinois, where a gigantic mutated chilopod, Megapede, is devouring thousands of dollars worth of crops. The team are unable to stop the creature when they first encounter it, and upon finding it again, they discover it has metamorphosed into a gigantic cicada. The insect's mating call is disrupting all radar in Chicago, and now H.E.A.T must find a way to silence the creature long enough to launch a counterattack.