The prospect of dissecting a frog is giving Nick nightmares so Wayne invents a dream machine that would go into Nick's dream. He kills the frog but is threatened never to come back into the dream world again. Amy, against her dad's wishes, goes in so she can annoy Nick, so now the family can't sleep or else they could die.

Wayne, wanting to please Nick, invents a Refuse Ingesting Protozoa or RIP that can eat anything. Jennings, who is being tracked by an environmentalist, puts toxic waste in Wayne's invention. RIP infected Quark, Quark infected the mail-man and so on. Now Wayne and family must stop these garbage-eating-zombies and get them to Jentech West where there is a high security system.

Wayne's Chameleonator makes people invisible. The Chameleonator was originally made to change the people's skin color, so they wouldn't need to use make-up anymore. A mole in the company is telling another company about the invention. Amy and Wayne must stop the mole and get his invention back from the company that took it.