Wayne, Diane, and Amy are accidentally shrunk to near-microscopic size. Soon after, Grandpa Murdock (Eugene Roche) drops by to pick up his grandson for a fishing trip. Nick feigns illness to avoid going with his grandfather, who then leaves, but not before inadvertently swallowing his mini-relatives—van and all. Nick interprets Wayne's help message in the newspaper and realizing what has happened, rushes to his family's aid.

Wayne becomes concerned about his family's safety and invents a security system for their protection. F.R.A.N. (Petrea Burchard), the Felon Repeller and Accident Neutralizer takes her duties very seriously and involves herself in every facet of the household. Diane is wary of the overprotective computer, not realizing that F.R.A.N. has developed a mind of her own. When Wayne decides to pull the plug, F.R.A.N. holds the Szalinskis under "house arrest." Wayne and his family try to stop F.R.A.N. before it's too late.

Wayne invents something that could make your vision perfect so Nick tries it out and can see practically anything, even dead people. He befriends a "friendly" ghost who gets into Wayne's body and Nick realizes that the ghost isn't all that good. So he along with Wayne attempt to get control of his body so they can get the ghost out.