Resus is always falling ill and suffers from a permanent case of hypochondria.Green activist Russell Swampy warns GHOUL boss Greystoke McDread of the dangers of overfilling the Underlands. The warning is ignored and when the Underlands reaches its maximum ‘evil' capacity, pure evil starts to ooze out, unleashing a terrible virus on Scream Street.Luke, Cleo, Resus and Luella hunt for somewhere safe, but they get trapped by the infected Scream Street residents and Cleo and Luke get bitten by their own parents! With Werewolf Luke and a crazed Cleo now after them, Resus and Luella are on the run to find a cure. Whilst Resus always gets ill, he is in fact resistant to this virus. Resus and Luella try to concoct a cure, but just as she does so the infected break into the Emporium…

Otto is up to no good and is taking things that don't belong to him. The friends must stop him and return the possessions to their rightful owner.

Luke is used to putting off his homework but the more he puts it off, the bigger the burden grows. Until eventually his homework turns into an unmanageable monster.