Zane and Steve visit Aspen, Hollywood, and San Diego to challenge their mixology prowess and debunk some popular drinking myths. They make some new friends by investigating and celebrating everything Sinatra, and set out to discover how many drinks it takes for Chad-the-sound-guy to become his inebriated alter-ego.

Steve insists on finding an astronaut jumpsuit and Zane takes them to a brewery celebrating the patron saint of beer in Houston. They re-discover the pains when competing in an ice drinking contest, and later, chase some pigs aroung in the mud.

Zane and Steve explore the American Southwest with a stop in San Antonio. They take a ride down the famous river walk, investigate the term "brewstillery", and celebrate the cities' heritage with a bull ride.