The series premiere takes Zane Lamprey to Phoenix, Arizona. He meets an illegal tequila moonshiner, makes a monster margarita and invents the ranch dressing beer-bomb.

Zane visits Santa Fe, New Mexico, where he meets a master margarita maker, drinks a beer that can kill chickens and eats some of the hottest chili pepper sauce in the state.

Zane rolls into Austin, Texas, where he infuses vodka with fruit, drinks the hottest bloody mary in town and tries his hand at an Austin tradition, spiking a watermelon.