Following consultant brain surgeon Omar Pathmanaban at Salford Royal Hospital in Greater Manchester as he operates on Adyita, who has a rare tumour that has been growing in his brain since birth and Emmanuel who has a malignant tumour so deep in his brain that Omar will have to operate through the nose.

Following consultant heart surgeon Inder Birdi at the Cromwell Hospital as he performs open-heart surgery on 70-year-old retired engineer Mike and fixes 59-year-old Sara's leaking heart valve using state-of-the-art technology to operate through a 3cm incision.