A reunion in New Orleans is an initiation for Alex when a former college friend seductively bites her neck and begins a transformation that can only be completed when Alex commits her first murder. She begins craving Nick in a way she never would have ordinarily imagined, and it is up to the rest of the Legacy to save her, and save Nick's life.

The Legacy members continue with their struggle to save Nick from Alex and Alex from becoming a vampire. But the evil forces are working double time trying to convince Alex to kill Nick in order to complete her transformation.

A shadowy and dangerous cult of youths is suspected in a string of arson attacks on churches. A member of the Boston Legacy House, Kristin Adams, searches for her teenage brother who has been abducted by that cult.