After her beloved dog passes away, an adopter comes to VRC hoping to fill the void in her heart. Louise and Matt rescue a dog that was hit by a car. And Tia's appearance on The Daily Show with Jon Stewart is threatened when her dog gets sick.

After risking life and limb to rescue a scared pit bull, Tia finds herself battling with a local shelter over the dog's fate. And, after a long recovery, a dog that was rescued from the brink of death finally has a shot at a forever home in Boston.

A new season brings new challenges as Villalobos Rescue Center expands beyond New Orleans and into the surrounding swamps, opening a satellite shelter in nearby Assumption Parish.