After rescuing 30 hybrid wolf-dogs, Tia, Tania, and the twins return to Texas. In the French Quarter, the pandemic has forced Tia to shut down her restaurant, and Toney and Earl band together to deliver meals to the elderly using Tahyo Tavern's resources.

On the streets of New Orleans, the VRC crew is on a mission to catch a runaway dog. A Californian family wants a new furry family member, a paralysed pup named Polly takes a trip to the vet, and Mariah pitches a fundraising idea to the parolees.

VRC is at its limit when the amount of rescues and drop-offs rise; Lizzy and Toney travel to a remote part of the city to save a trio of orphaned dogs in a dire state; veteran tenant Lil Rocky faces a cancer scare.