After being diagnosed with a degenerative neurological disorder, Chicago Mayor Tom Kane must set aside his personal issues as he attempts to run the city with an iron fist, while also dealing with the upcoming gubernatorial primary.

With a new, powerful entry in the race, Kane and his people flex their political muscles to maintain their hold. Meanwhile, a worried Meredith suspects her husband is keeping something from her.

With Zajac's campaign gathering steam, Kane needs to adjust to his health situation; Miller digs deep to come up with some embarrassing dirt on Gov. Cullen.