The "Reed curse" plagues Teddy as the wedding approaches, with Big Al trying to find a donor and Charley afraid to be more intimate with Wes.

The Reed siblings rush to the hospital to be with Alex during Big Al's transplant; and while they wait, Teddy meets Sorenson's old girlfriend. Also: Charley treats an injured classmate of Jesse's; and Georgie runs into Brian.

Alex drags her mother and siblings to Springfield where she's giving a speech, but they find themselves stuck in a blizzard.