Reed helps Chardonnay fulfill a last wish; Charley encourages Wes to date Jesse's teacher, but soon regrets it.

The "Reed curse" plagues Teddy as the wedding approaches, with Big Al trying to find a donor and Charley afraid to be more intimate with Wes.

The Reed siblings rush to the hospital to be with Alex during Big Al's transplant; and while they wait, Teddy meets Sorenson's old girlfriend. Also: Charley treats an injured classmate of Jesse's; and Georgie runs into Brian.