Outside of Italy, rebellion stirs and the Cardinals fear they'll lose their power, while plans begin for Lucrezia's next marriage.

Cesare loses his lover and his daughter, leading to a painful defeat, and Lucrezia's betrothal becomes politically and emotionally complex.

Cesare's renegade generals mount a rebellion against him, while those close to Rodrigo conspire against him, all on the eve of Lucrezia's wedding.