The three doctors fall out when a Consultant refuses to operate on their heart patient because he is a heavy smoker. Meanwhile Will's marriage suffers another setback.

Jack is caught in a dilemma when he has to tell his best friends that Chloe has cancer, and his relationship with Beth continues to deteriorate.

Jack has to deal with a patient whose employer will not let her rest. Meanwhile, Isabel and Ken's romance takes a dive when their ward collapses.