Rita Saverino made a career in the cold-eyed world of investment banking, where success and failure are measured in profit and loss. Now this warm and affectionate mother of two boys must face the worst kind of risk analysis. She must calculate whether to have a rare and potentially fatal surgery in an effort to excise the extensive cancer in her abdomen. The surgery will remove her liver, stomach, kidney and intestines from the abdomen, cut away the adherent sarcoma, and finally put the organs back into Rita's body. Dr. Tomoaki Kato is world famous for this operation, which has been criticized by some who says that not enough studies exist to support such a radical procedure. For Rita's family, it is a gamble for life, a wager they cannot refuse.

Marina, Diana and Katie--the ER's compassionate, competent and sometimes hilarious nurses from the first season of NY MED--return. They confront everything from subway tragedies to romantic suitors feigning medical syndromes. In this first episode, they treat a young woman with a bizarre injury that leaves the staff both baffled and impressed.

Hugo Razo grew up in a modest home in a small California city where young Mexican-Americans like him were often pressured to join gangs. He struggled in high school and says most people thought he'd most likely end up doing physical labor of some kind such as janitorial work. But his determination to prove them wrong led him to turn it around and get on the path that would lead to his becoming a skilled ER doc at a major hospital. When a young professional couple arrives in the ER injured after a violent home invasion, Dr. Razo is the one who treats and ultimately reassures the pair that life will go on and their wounds, both physical and emotional, will heal. With his imposing stature and physique, Dr. Razo is also adept at assisting security guards when they have to subdue the occasional unruly or violent patient.