John Doe holds Dr. Maria Benavidez hostage as an unknown entity continues to blindly lead him to an undisclosed location, and Claire and Wes further their investigation into John Doe's past whereabouts and begin to uncover what his next target is.

While Minx tries to persuade a disillusioned Henry to play one more game for Drill, the race is on for Claire and Wes to thwart John Doe from causing a major incident that could potentially kill millions of people.

Claire speaks with Sean, who has no memories of her or their life together, and tries to get him to remember something.. anything about his past; Wes has an epiphany and heads back to Mali to take another look at the fulgurite, and Lena keeps a watchful eye on Minx to make sure that her conversations with Drill have ceased.