While John Doe continues on his mysterious mission, Claire attempts to hold back his sketch from the other bureau offices while she investigates his identity on her own, Lena is aware and not too pleased that Wes has been speaking with Claire about a case, and Drill continues playing his dangerous game with Minx, Henry and Harper.

John Doe holds Dr. Maria Benavidez hostage as an unknown entity continues to blindly lead him to an undisclosed location, and Claire and Wes further their investigation into John Doe's past whereabouts and begin to uncover what his next target is.

While Minx tries to persuade a disillusioned Henry to play one more game for Drill, the race is on for Claire and Wes to thwart John Doe from causing a major incident that could potentially kill millions of people.