Rose becomes nervous when her latest beau, Arnie, invites her to go on a cruise with him. The two will be sharing a stateroom, which would be the first time Rose has slept with a man since her husband Charlie's death several years prior. Meanwhile, Dorothy and Sophia face off in a gin rummy marathon.

Blanche's sister Virginia stops by for a visit, and tells Blanche some horrific news -- she's dying from renal failure, and needs Blanche's kidney to survive. Meanwhile, the girls babysit for a neighbor.

Dorothy begins dating a doctor who Blanche also has an eye on. Unfortunately, the good doctor also has an eye on Blanche, and makes a pass at her.