31-year-old Katelyn undergoes cutting edge laser surgery to tackle her epilepsy and 61-year-old Jackie is losing feeling and function in her arms and legs; without surgery she faces paralysis.

Sixty-three-year-old Andrew is rushed in for urgent brain surgery to remove a tumour from the right side of his brain. Fifty-two-year-old Sarah undergoes a brain implant procedure in the hope of ending decades of excruciating cluster headaches. Also, 77-year-old Chris needs an operation to drill away the extra bone growth on his cervical spine.

Surgeons race to remove a life-threatening brain mass from 34-year-old Milton, operate on Annie's spinal tumour to prevent paralysis, and perform complex keyhole surgery on Rob's spine.