Shaun has a rare condition, acromegaly, that causes his hands and feet to keep growing. Sofia needs an operation to alleviate a Chiari malformation: her brain is pushing into the spinal canal.

James, 63, is losing feeling and function in his hands and fingers. Surgeons must act fast to remove disc and bone from his neck. It's up to them to save James from an uncertain future.

Documentary following life at Liverpool's Walton Centre for neurology and neurosurgery, beginning with a patient who must faces brain surgery while awake.