Surgeons begin to fear that without urgent surgery Fifty-three-year-old Theresa could become paralysed after she's rushed to hospital with weakness in her arms and legs.

Shaun has a rare condition, acromegaly, that causes his hands and feet to keep growing. Sofia needs an operation to alleviate a Chiari malformation: her brain is pushing into the spinal canal.

James, 63, is losing feeling and function in his hands and fingers. Surgeons must act fast to remove disc and bone from his neck. It's up to them to save James from an uncertain future.