Ashton Kutcher shares his terrifying battle with a rare disease that almost took his life, and in their first interview together, he and his twin brother Michael share the emotional story of a childhood defined by extreme life and death health challenges. Michael talks about being born with cerebral palsy, then enduring a life-saving heart transplant at 13, and the brothers unravel a complicated relationship as twins with such different lives.

Oprah Winfrey and her longtime friend, author and journalist Maria Shriver sit down with Dr. Agus to take an unflinching look at women's health, specifically a misunderstood and often mistreated issue: menopause.

Comedian and television personality Howie Mandel talks to Dr. Agus about his debilitating, lifelong struggle with obsessive-compulsive disorder. Joined by daughter Jackelyn, who suffers from her own OCD and anxiety, we discover how Howie's obsession with control has impacted his life, his career and the people he loves most.