Marj Bowen is a veteran nurse who faces surgery and the fact that her job, to which she was dedicated, will no longer be possible for her to carry out. Head nurse Marge Bowen dispenses hope as well as pills, especially to a young singer who fears a throat operation.

Medical Center doesn't stray too far from its basic premise for a love story. The girl in Dr. Gannon's life is played by Shelby Grant. She is a tour director the doctor meets while on a Mexican vacation.

Doctor Gannon begins to treat his boyhood football idol and is startled to discover that ailing Ollie Wayne (Forrest Tucker) does not really seem to care whether or not he is cured. Gannon (Chad Everett) delves into the patient's personal life to find reasons for his peculiar behavior.