Martin Sheen guest stars as a young minister whose heart condition flares up to jeopardize his chances of maintaining a foundation for parolees.

Marj Bowen is a veteran nurse who faces surgery and the fact that her job, to which she was dedicated, will no longer be possible for her to carry out. Head nurse Marge Bowen dispenses hope as well as pills, especially to a young singer who fears a throat operation.

Medical Center doesn't stray too far from its basic premise for a love story. The girl in Dr. Gannon's life is played by Shelby Grant. She is a tour director the doctor meets while on a Mexican vacation.