After six seasons, on the 117th episode and series finale of "Supernanny," Jo Frost travels to Houston, Texas to work with a family whose mom died of breast cancer a year earlier. Jo lost own her mother to breast cancer when she was growing up. "To me, this is the end of the world!," laments 6-year-old Michael, who misses his mother terribly and feels his memories of her slipping away. Dad Gary is trying his best to raise Michael and younger sons Sean, 4 and Dylan, 3, on his own, but he's overwhelmed and can't bring himself to enforce the rules his wife established for the boys. The boys act out, there's lots of sibling fighting and their screaming can be deafening at times. In addition, Dylan still isn't potty trained, and all the boys are picky eaters and devoted to unhealthful foods. When Sean acts up over not getting candy and Jo puts him into his first time out in ages, an epic standoff takes place. Can Jo help this grieving family find peace?

Working parents, Jessica and CJ Braido, feel they're being overrun by their four small children and are at a loss at how to come together on their parenting perspectives. The only thing they can agree on is using electronics as a babysitting device in order to give them some peace. Can Jo get these parents to come together to work as a united front, or will war break out in the Braido household?

The Corry's are a military family struggling to discipline their four daughters. While Ben, the father, is away with the army for months at a time, Maria, the stay-at-home mom, is left dealing with their rambunctious children and navigating her post-partum depression. Will Nanny Jo be able to dive into the trenches and rescue this family?