Four years after the Summit Meadow case went cold, hikers found a human skull. There's no proof it's related to the hand discovered earlier, but it allows for a facial reconstruction that shows what Jane Doe may have looked like. But that generates no leads. Decades pass; Kim Tucker's son Cullen is now an investigator and is assigned the case. Using new DNA science after almost 40 years, Jane Doe is finally identified! Now Cullen wonders how did she end up dead in Yosemite — and given it was likely murder, who did it?

We meet Jane Doe's childhood friends and find out about her early life. After her brother's suicide, she began a spiritual quest and lived near Yosemite in a so-called cult. There she may have crossed paths with two other men who may have been involved in her death. Investigators name their most likely perpetrator.

Experienced hiker Meredith Emerson goes missing on Blood Mountain, Georgia and a massive search begins. Investigators soon learn of two other missing hiker cases that have ended in murder. Has a serial killer taken Meredith? Can she be rescued in time?