A seemingly routine flight carrying convicted murderer Gordon Locke and the deputy sheriff escorting him from northern California to imprisonment becomes a hazardous one for Cass and Stan when the 'deputy" proves to be Locke's confederate who has engineered an escape plot that unfolds after takeoff. When the plane crash lands, Stan finds himself stranded and with a sprained ankle.

Annette Collier's, an industrialist's daughter, anticipated flying lesson with Cass Garrett becomes a kidnapping-extortion nightmare when one of her father's employees hijacks the airplane. The only clue to the whereabouts of Cass's hijacked plane is a jumbled radio message Stan (Todd Susman) believes is in code. The abductors are demanding US$600.000 from her father, Herbert Collier.

A scheming crop duster (Cameron Mitchell) hires Cass to fly one of his planes. Little does he know that our boy is on assignment by the government to see if he is doing something illegal (of course, he is) behind that crop-dusting front.