As the 2000s unfold, diverse voices like Chelsea Handler and George Lopez get their seat behind the late-night desk, while Jon Stewart and Stephen Colbert take the news into their own hilarious hands.

Jimmy Fallon, Stephen Colbert, and Trevor Noah follow in Leno, Letterman, and Stewart's footsteps, and new hosts James Corden, Seth Meyers, Samantha Bee, Amber Ruffin, and Desus + Mero confront Donald Trump – and COVID-19.