When Latashia Nevitt vanishes into thin air on her way to a convenience store, Sgt. Jeffrey Coleman and partner Bill Joyner investigate. But after giving lie detector tests to Latashia's mother and husband and sending canine units on the trail of Latashia's scent, Coleman and Joyner are no closer to finding her.

When an aspiring model disappears, Det. Joe Gentile suspects an online predator may have kidnapped her. And Det. Pam Childs races to find a missing man with mental disabilities before he becomes a victim of street violence.

A woman reports her husband missing the day after their second wedding anniversary; a missing hotel guest is spotted on surveillance video leaving the establishment.