Detectives Ayanna Corbin and Michael Cochran rush to save a missing mother of four children who's left behind a suicide note. And Detective Bob Berent goes looking for a disoriented and confused woman who's wandering the streets of Chicago--an easy target in the big city.

When Latashia Nevitt vanishes into thin air on her way to a convenience store, Sgt. Jeffrey Coleman and partner Bill Joyner investigate. But after giving lie detector tests to Latashia's mother and husband and sending canine units on the trail of Latashia's scent, Coleman and Joyner are no closer to finding her.

When an aspiring model disappears, Det. Joe Gentile suspects an online predator may have kidnapped her. And Det. Pam Childs races to find a missing man with mental disabilities before he becomes a victim of street violence.