Week four of Top Chef Masters brings together distinguished chefs Anita Lo (Annisa), Douglas Rodriguez (Alma de Cuba), John Besh (Restaurant August) and Mark Peel (Campanile). The Masters find their hands tied in the Quickfire Challenge as they must cook an egg with one hand tied behind their back (All-Stars Challenge, Season Three of Top Chef), and then must create culinary magic to awe their high-profile guests which include Neil Patrick Harris. One chef moves on to the Champions Round.

The final team of four chefs face a food group they typically avoid for this week's Quickfire: they have to re-create a junkfood classic (Season One, Top Chef).  Michael Chiarello (Bottega Restaurant), Rick Moonen (RM Seafood at Mandalay Bay), Nils Noren (French Culinary Institute) and Lachlan McKinnon Patterson (Frasca Food & Wine) are then put on the spot as they are pushed to make the perfect three-course mini-meal. Flipping Out's Jeff Lewis and Jenni Pulos guest star, and one chef moves on to the Champions Round.

Knives are drawn and the display of extraordinary talent begins in the most ordinary of places – a grocery store where the chefs are met with the classic Quickfire "Aisle Trial" (Season 3, Top Chef). Master chefs Roy Yamaguchi (Roy's Restaurants), Art Smith (Table Fifty-Two), Michael Cimarusti (Providence) and Jonathan Waxman (Barbuto) pass the Quickfire round and are faced with a mystery box from which they must concoct their Elimination Challenge meals. One chef moves on to the Champions Round.