Operating on an extremely tight budget, the chef's must create the perfect amuse bouche using only what they can find in a vending machine (Season 2, Top Chef). Master chefs Wylie Dufresne (wd~50), Suzanne Tracht (Jar), Graham Elliot Bowles (Graham Elliot Restaurant) and Elizabeth Falkner (Orson) find themselves "lost" as they are challenged to make a meal inspired by the hit TV show, using ingredients such as fish, wild boar, fresh fruits, and other island specialties. Lost co-creators, executive producers and writers Carlton Cuse and Damon Lindelof guest star, and one chef moves on to the Champions Round.

The chefs take their skills to the street. Rick Bayless (Frontera Grill), Cindy Pawlcyn (Mustards Grill), Wilo Benet (Pikayo) and Ludo Lefebvre (Ludo Bites) set out to create a Quickfire dish based on a color (Season 2, Top Chef). Next up the chefs hit the streets for the elimination challenge to make offals for Los Angeles pedestrians. One chef moves on to the Champions Round.

Week four of Top Chef Masters brings together distinguished chefs Anita Lo (Annisa), Douglas Rodriguez (Alma de Cuba), John Besh (Restaurant August) and Mark Peel (Campanile). The Masters find their hands tied in the Quickfire Challenge as they must cook an egg with one hand tied behind their back (All-Stars Challenge, Season Three of Top Chef), and then must create culinary magic to awe their high-profile guests which include Neil Patrick Harris. One chef moves on to the Champions Round.