It's the first day of school at Acme Looniversity - the Harvard of being stupid – where we find fraternal twins, Babs and Buster Bunny meeting their new friends - tough chick Sweetie Bird, self-effacing sweetheart Hamton J. Pig, and narcissist clown, Plucky Dug. These young dreamers all share the same big plans - to learn how to be professional toons - and their journes begins now.

Rivals Buster and Plucky decide to throw an epic pizza party and are shocked to find out they're actually getting along while Babs and Sweetie get into their first roommate disagreement.

Babs realizes Acme Loo's school paper has closed so she starts a new one with her pal Sweetie. But when Plucky starts a gossipy tabloid to compete against them, which paper will come out on top?