In the Savannah, Dr. Bonnie must perform a critical surgery on zebra Zaide's badly damaged tail. Tiger Indrah gets an incredible tenth birthday surprise, and Dr. Sarah is determined to solve spider monkey Isobella's medical mystery.

In order to navigate the COVID-19 global pandemic, the staff must ensure proper care for their animals. Keepers spring into action when urgent dental surgery is needed for elderly tiger Binjai, and a family of cotton top tamarin monkeys must be relocated.

Problems arise when beloved African wild dog Manna undergoes critical surgery. Treatment is needed for an elderly croc's ruptured cornea, and Jose and Kristie give pygmy hippo Felix the VIP treatment.