Up-and-coming singer Tammy Wynette gets a big break when she's asked to open for her idol, country legend George Jones. The two have an immediate romantic connection and undeniable musical chemistry, but their would-be pairing faces a major obstacle: Tammy's husband Don Chapel.

Running away together turns out to be more difficult than George and Tammy imagined, with Tammy's past threatening to derail their hopes for marriage, and with George's past standing in the way of their future as a recording duo.

The President and First Lady of Country Music are on top of the world: hit after hit, award after award, and a new baby to boot. However, when a once-in-a-lifetime opportunity presents itself in Las Vegas, Tammy is forced to question whether George can handle the pressures of superstardom.