Paul's dreams of a happy retirement have been ruined since his face started swelling so dramatically that he struggles to see. He's been to multiple specialists but no one has given him a diagnosis and his family are desperately worried. "It's distressing", says his daughter. "Is it something life threatening? We don't know."While the team try to help Paul, Michael presents them with another unusual case. Judy's problems began in 2007 when she started being sick and finding swallowing uncomfortable. She's now reached a point where she struggles to eat solid food and has lost 10 kilos in the last three months. Her family are fearing the worst. "She is just skin and bone. It's just going to kill her," says daughter Jayne.

Twelve medical experts race to diagnose a man with a life-threatening skin condition and a mother suffering a dramatic decline in health.

In episode three, the team of 12 doctors aim to diagnose a young woman suffering with dramatic weight gain and hair loss, and another who has suddenly gone blind in one eye.