The almost-broke and unemployed Lee finds out that Coreco Pharmaceuticals is looking to hire sales reps -- female sales reps. He takes a chance and goes into the interview dressed in heels, a skirt and makeup. The transformed Lee gets hired -- as a woman. Lee wants to stay true to his agreement with Angel that, if one of them is working, then the other will be too, so he tells Angel what he has to do if he wants a job at Coreco. Angel, who is miserable working at a fast-food dump, is desperate to make a change; he decides to swallow his pride and go for it. Unfortunately he tanks his interview, but when he fixes the boss's car, he too is hired - also as a woman.

When newly-employed Lee and Angel go out into the field as sales reps for the first time dressed as women, former salesman Lee is confident he'll be successful while Angel is concerned his background as a mechanic will not serve him well. But when Angel's flirtatious ways earn him sales while Lee constantly strikes out, Lee tries subtly to elicit advice from wife Connie on ways a woman can flirt with a man.

Angel becomes jealous when Lee blows off their trivia game to hang out with Kristin, and Kelly and Grace manage to worsen the situation.