Tom Baldwin is arrested by the NTAC for a crime he swears he doesn't remember committing; Shawn guides Isabelle through the things she missed in life due to her sudden transformation into an adult.

Tom and Diana try to foil a kidnapper who's going after 4400 children. Meanwhile, Shawn's past comes back to haunt him.

Tom and Diana continue their search for a mysterious kidnapper who is targeting 4400 children, while Shawn's relationship with Isabelle causes concern at the Center.