Richard is forced to cope with his infant daughter's sudden transformation into a woman and a horrendous change in his wife, Lily. Meanwhile, Dennis Ryland is injured during Congressional hearings, and the person responsible may be part of a radical 4400 splinter group.

Tom and Diana continue to pursue the Nova Group; Maia starts school at the 4400 Center; Isabelle gains new insight into her role in the future.

Tom Baldwin is arrested by the NTAC for a crime he swears he doesn't remember committing; Shawn guides Isabelle through the things she missed in life due to her sudden transformation into an adult.