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An aggressive male patient is rushed into Newham Hospital Emergency Department in East London, while shouting and swearing at doctors. Police are forced to physically restrain him, while Dr Nick and a team of clinicians try to determine what's wrong. Dr Sarah assesses 36-year-old David for a significant facial wound and swelling around his eye socket.

Police are called to Belfast's Royal Victoria Emergency Department when a female patient becomes aggressive, but Dr Rachel recognises she's suffering from a mental health crisis. Dr Orla is trying to save the life of 81-year-old Theresa who is struggling to breathe. In East London, at Newham Hospital, Dr Daniel is concerned for a man rushed in after being found unconscious in a kebab shop.