At Newham Hospital Emergency Department, a drunk man with knife wounds in his chest and hand refuses to cooperate, until heavy bleeding threatens his vital organs. In Belfast's Royal Victoria A&E, an 81-year-old woman has suffered a brutal injury to her leg from slipping in her muddy garden and smashing her shin into a concrete bar.

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An aggressive male patient is rushed into Newham Hospital Emergency Department in East London, while shouting and swearing at doctors. Police are forced to physically restrain him, while Dr Nick and a team of clinicians try to determine what's wrong. Dr Sarah assesses 36-year-old David for a significant facial wound and swelling around his eye socket.