A man who fell through a window has a phobia of needles, which leads him to refuse any kind of pain relief and even attempt to discharge himself before his injuries are treated. An aggressive patient is brought in by four police officers after smashing up his mother's home, and has to undergo a toxicology test. Dr Audrey Fox tries to save the life of a patient who has overdosed, and a woman suffers a head injury after slipping on a slice of pizza her husband had left on the floor for their dog to eat.

The hospital security team is called to reception after a suspected drug user is found passed out on the floor, while ex-factory worker Claude is determined to discharge himself after a bang on the head. Sixty-eight-year-old former fire fighter Stephen is brought in after passing out at home, and blood tests reveal that he has sepsis, an infection that causes more deaths than cancer.

Medical staff are faced with an aggressive patient who was bought in by police after being pushed down a flight of concrete stairs, and is shouting and swearing. Doctors are concerned that his behaviour could be as a result of a serious head injury. Doctor Andrew administers morphine to help a woman in agony, but the medics grow worried when her screams turn to silence.