Zak Bagans and the "Ghost Adventures" crew investigate the Irvington, Indiana, home where H.H. Holmes, America's first serial killer, killed a nine-year-old boy. The current owner believes dark and sinister forces have overtaken the property, leaving her vulnerable to possession.

Zak Bagans and the crew head to Illinois in search of the spirit of infamous serial killer John Gacy. Their investigation leads them to the Old Joliet Prison, where they hope to come face-to-face with the Killer Clown himself.

Zak Bagans and the team travel to Council Bluffs, Iowa, to investigate the jail that once held Jake Bird, a prolific serial killer who may have killed as many as 46 people and was said to have placed a deadly curse on the men who convicted him.