The Human Torch pursues Medusa, only to stumble into her relatives, the Royal Family of the Inhumans. The Inhumans mistake the Fantastic Four for enemies.

The Fantastic Four journey to Attilan and assist the Royal Family in restoring Black Bolt to the throne, but must contend with Black Bolt's treacherous brother Maximus and the swarms of Inhumans loyal to him.

The Invisible Woman falls under the sway of the Psycho-Man, who alters his personality into the malevolent Malice, pitting her against her own family.