The Fantastic Four can't defeat Galactus, so they try to convince his slave and herald The Silver Surfer to help them somehow.

The Skrulls may have been defeated, but they want revenge, so they send a superior genetically modified Srkull - Superskrull - to take down the Fantastic Four.

Dr. Doom imprisons the Fantastic Four in his castle. Sue manages to convince Doom to tell her about his origin, in order to buy time for the other three to find a way out.