When Michael finds out a patient with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life. Meanwhile, a female firefighter who appears to be disoriented is brought to Holt Neuro for evaluation.

Rita's surprise Thanksgiving reunion with her son is interrupted when he has a motorcycle accident and it's up to Michael to save him. Meanwhile, Dr. Sykora and Dr. Barnes resuscitate a patient with a DNR.

Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.