While at the clinic, Michael runs into a former football star that he performed successful surgery on years ago, and is now a shell of his former self, living on the streets. At Holt Neuro, Michael examines a patient who suffers from post-traumatic stress disorder.

When Michael finds out a patient with a malignant brain tumor committed a horrible crime, he struggles with whether to save the man's life. Meanwhile, a female firefighter who appears to be disoriented is brought to Holt Neuro for evaluation.

Rita's surprise Thanksgiving reunion with her son is interrupted when he has a motorcycle accident and it's up to Michael to save him. Meanwhile, Dr. Sykora and Dr. Barnes resuscitate a patient with a DNR.