Michael and Kate are forced to work together to try and save a patient with a deadly virus. Meanwhile, at Holt Neuro, as Michael treats a nervous bride-to-be who is experiencing headaches, he notices her mother is exhibiting symptoms of a serious condition.

While tending to patients at the clinic during a blizzard, Michael shows signs of a severe condition that requires immediate surgery.

Michael and E-Mo disagree about how to treat a patient with a brain tumor. Meanwhile, a teenage girl gives birth at the clinic and immediately runs out, leaving the baby behind.